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KMID : 1034720190110020139
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Journal of Neurosonology and Neuroimaging
2019 Volume.11 No. 2 p.139 ~ p.144
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Body Mass Index and Brainstem Raphe Nucleus Echogenicity in de novo Parkinson’s Disease
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Kim Hye-Weon
Han Sang-Won
Baik Jong-Sam
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Abstract
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Background: Weight loss is common in Parkinson’s disease (PD) and there may be many related factors, especially depression and cognitive decline. The application of transcranial sonography (TCS) with respect to the mesencephalic midline may be useful for detecting depression, a risk factor for the development of PD. This study aimed to investigate the association of body mass index (BMI), depression, and cognitive decline using TCS findings of the brainstem raphe (BR).
Methods: We collected data of patients with de novo PD who were aged ≥40 years between January 2015 and January 2018. The patients’ demographic characterisitcs, symptom progression, and motor disabilities were documented at baseline.
Results: A total of 165 patients met the inclusion criteria and were enrolled in this study. Patients with abnormal BR echogenicity showed significantly higher Hamilton depression rating scale (HAM-D) score and lower BMI than patients with normal echogenicity, suggesting that abnormal BR echogenicity was associated with depression and lower body weight. Although there was no significant relationship between BMI and HAM-D score, a trend toward higher HAM-D scores was observed for low BMI patients (r=-0.116, p=0.082). BR-echogenicity-adjusted scatterplots of the relationship between HAM-D score and BMI showed that the HAM-D score was inversely related to BMI in de novo PD patients (r=-0.217, p=0.026).
Conclusion: The findings of this study suggest that depression is related to weight loss in PD patients and that TCS findings with abnormal raphe nucleus echogenicity can be a good indicator of weight loss and depression in patients with de novo PD.
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KEYWORD
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Body mass index, Depression, Parkinson disease, Raphe nuclei, Ultrasonography
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